Membrane proteins account for 25 – 30 % of a cell’s proteome and function as fusion factors, adhesion molecules, receptors, channels etc. Their membrane-spanning helices can induce dimerization or oligomerization, specific protein/lipid interactions, drive membrane fusion, catalyze lipid flip/flop, serve as substrates for intramembrane proteases etc.
To understand the mechanisms by which transmembrane domains (TMDs) self-interact, their conformational dynamics, and their ability to interact with surrounding lipids.
To elucidate the functional relevance of these interconnected structural properties.
The lab hosts modern equipment to do experiments in molecular biology, biochemistry and biophysics.