Publikationen
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2023
Werner, N.T., Högel, P., Güner, G., Stelzer, W., Wozny, M., Aßfalg, M., Lichtenthaler, S.F., Steiner, H., Langosch, D. (2023): "Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by gamma-secretase", Commun. Biol., 6(1): 177, DOI: 10.1038/s42003-023-04470-5
Schmidt, F., Fitz, K., Feilen, L., Okochi, M., Steiner, H., Langosch, D. (2023): "Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.", J. Biol. Chem. Mar 19:104626, online, ahead of print, DOI: 10.1016/j.jbc.2023.104626
2022
Güner, G., Aßfalg, M., Zhao, K., Dreyer, T., Lahiri, S., Lo, Y., Slivinschi, B.I., Imhof, A., Jocher, G., Strohm, L., Behrends, C., Langosch, D., Bronger, H., Nimsky, C., Bartsch, J.W., Riddell, S.R., Steiner, H., Lichtenthaler, S.F. (2022): "Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for gamma-secretase activity.", EMBO Mol Med, 14(10): e16084. DOI: 10.15252/emmm.202216084
Papadopoulou, A., Stelzer, W., Silber, M., Schlosser, Ch., Spitz, Ch., Haug-Kröper, M., Straub, T., Müller, S.A., Lichtenthaler, S.F., Muhle,-Goll, C., Langosch, D., Fluhrer, R. (2022): "Helical Stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage", Scientific Reports, 12(1), DOI: 10.1038/s41598-022-24772-8
Ortner, M., Stelzer, W., Schmidt, F., Guetlich, M., Langosch, D. (2022): "An advanced yeast model to investigate the interplay between structure and function of human gamma-secretase and its substrates", Biophys J., Vol. 121(3), Suppl. 1, 342A, https://doi.org/10.1016/j.bpj.2021.11.1047
2021
Heckmeier, P.J. and Langosch, D. (2021): "Site-specific Fragmentation of Green Fluorescent Protein Induced by Blue Light", Biochemistry, Aug. 17; 60 (32), DOI: 10.1021/acs.biochem.1c00248
2020
Spitz, C., Schlosser, C., Guschtschin-Schmidt, N., Stelzer, W., Menig, S.,Götz, A., Haug-Kröper, M., Scharnagl, C., Langosch, D., Muhle-Goll, C., Fluhrer, R. (2020): "Non-Canonicalshedding of TNFα by SPPL2a is determined by the conformational flexibility of its transmembrane helix.", ISCIENCE, 23(12), DOI: https://doi.org/10.1016/j.isci.2020.101775
Xiao, Y., Zeng, B., Berner, N., Frishman, D., Langosch, D., Teese, M.G. (2020): "Experimental determination and data driven prediction of homotypic transmembrane domain interfaces.", Computational and Structural Biotechnology Journal, Vol. 18, 3230-3242, DOI: doi.org/10.1016/j.csbj.2020.09.035
Scheidt, H.A., Kolocaj, K., Konrad, D.B., Frank, J.A., Trauner, D., Langosch, D., Huster, D. (2020): "Light-induced lipid mixing implies a causal role of lipid splay in membrane fusion.", Biochim Biophys Acta Biomembr., online ahead of print, DOI: 10.1016/j.bbamem.2020.183438
Heckmeier, P.J., Agam. G., Teese, M.G., Hoyer, M., Stehle, R., Lamb, D.C., and Langosch, D. (2020): "Determining the Stoichiometry of SMall Protein Oligomers Using Steady-State Fluorescence Anisotropy.", Biophys. J., 119, 99-114. DOI: 10.1016/j.bpj.2020.05.025
2019
Stelzer, W. and Langosch, D. (2019): "Conformationally Flexible Sites within the Transmembrane Helices of Amyloid Precursor Protein and Notch1 Receptor", Biochemistry., 58: 3065-3068. DOI: http://dx.doi.org/10.1021/acs.biochem.9b00505
Götz, A., Mylonas, N., Högel P., Silber, M., Heinel, H., Menig, S., Vogel, A., Feyrer, H., Huster, D., Luy, B., Langosch, D., Scharnagl, C., Muhle-Goll, C., Kamp, F., Steiner, H. (2019): "Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage.", Biophys.J., Vol. 116(11): 2103-2120. DOI: https://doi.org/10.1016/j.bpj.2019.04.030
Götz, A., Högel P., Silber, M., Chaitoglou, I., Luy, B., Muhle-Goll, C., Scharnagl, C., Langosch, D. (2019): "Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP.", Sci Rep., 9(1): 5321. DOI: 10.1038/s41598-019-41766-1
Yücel, S.S., Stelzer. W., Lorenzoni, A., Wozny, M., Langosch, D., Lemberg M.K. (2019):"The Metastable XBP1u Transmembrane Proteolysis by Signal Peptide Peptidase.", Cell Reports, Vol. 26 (11), 3087-3099. DOI: doi.org/10.1016/j.celrep.2019.02.057
2018
Yucel, S.S., Stelzer, W., Lorenzoni, A., Wozny, M., Langosch, D., Lemberg, M. (2018):"Metastable XBP1u transmembrane domain mediates insertion into the ER membrane and intramembrane proteolysis by the signal peptide peptidase." bioRxiv/2018/322107, DOI: doi.org/10.1101/322107
Scheidt, H.A., Kolocaj, K., Kristensen, J.V., Huster, D., Langosch, D. (2018): "Transmembrane Helix Induces Membrane Fusion through Lipid Binding and Splay", J. Phys. Chem. Lett., 9, 3181-3186
DOI: 10.1021/acs.jpclett.8b00859
Liveslides.mp4
Högel, P., Götz, A., Kuhne, F., Ebert, M., Stelzer, W., Rand, K.D., Scharnagl, C., Langosch, D. (2018): "Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix", Biochemistry, 57(8): 1326-1337. DOI: 10.1021/acs.biochem.7b01197
2017
Julius, A., Laur, L., Schanzenbach, C., Langosch, D. (2017): "BLaTM 2.0, a Genetic Tool Revealing Preferred Antiparallel Interaction of Transmembrane Helix 4 of the Dual-Topology Protein EmrE." J. Mol. Biol., 429(11): 1630-1637. DOI: 10.1016/j.jmb.2017.04.003.
Langosch, D., Steiner, H. (2017): "Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics." Biol. Chem., 398(4): 441-453. DOI: 10.1515/hsz-2016-0269.
Schanzenbach, C., Schmidt, F.C., Breckner, P., Teese, M. G. & Langosch, D. (2017): "Identifying ionic interactions within a membrane using BLaTM, a genetic tool to measure home- and heterotypic transmembrane helix-helix interactions." Scientific Reports, 7: 43476, DOI: 10.1038/srep43476
2016
Stelzer, W., Scharnagl, C., Leurs, U., Rand, K.D., Langosch, D. (2016): "The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region" ChemistrySelect, 1: 4403-4407. DOI: 10.1002/slct.201601090 (submitted PDF version, Supporting Information)
Ried, C.L., Scharnagl, C., Langosch, D. (2016): "Entrapment of Water at the Transmembrane Helix-Helix Interface of Quiescin Sulfhydryl Oxidase 2."
Biochemistry, 55 (9): 1287-1290. DOI: 10.1021/acs.biochem.5b01239
2015
Winkler, E., Julius, A., Steiner, H., Langosch, D. (2015): "Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase."
Biochemistry, 54 (40): 6149-6152. DOI: 10.1021/acs.biochem.5b00986
Teese MG & Langosch D (2015): "The role of GxxxG motifs in transmembrane domain interactions."
Biochemistry, 54(33): 5125-35. DOI: 10.1021/acs.biochem.5b00495 http://dx.doi.org/10.1021/acs.biochem.5b00495.
Langosch, D., Scharnagl, C., Steiner, H., Lemberg, M.K. (2015):"Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics."
Trends Biochem Sci., 40(6): 318-327. DOI: 10.1016/j.tibs.2015.04.001
2014
Scharnagl, C., Pester, O., Hornburg, P., Hornburg, D., Götz, A., Langosch, D. (2014):"Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helix."
Biophys J, 106(6): 1318-1326. DOI: 10.1016/j.bpj.2014.02.013
Chia-yi Chen, Nicole S Malchus, Beate Hehn, Walter Stelzer, Dönem Avci, Dieter Langosch, Marius K Lemberg (2014):"Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u."
EMBO J, 33(21):2492-2506. DOI: 10.15252/embj.201488208
2013
Mudumbi, K.C., Julius, A., Herrmann, J., Li, E. (2013):"The pathogenic A391E mutation in FGFR3 induces a structural change in the transmembrane domain dimer."
J Membr Biol., 246(6): 487-493.
Pester, O., Götz, A., Multhaup, G., Scharnagl, C., Langosch, D. (2013):"The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics."
Chembiochem, 14(15): 1943-1948.
Kirrbach, J., Krugliak, M., Ried, C.L., Pagel, P., Arkin, I.T., Langosch, D. (2013):"Self-interaction of transmembrane helices representing pre-clusters from the human single-span membrane proteins."
Bioinformatics., 29(13):1623-30. doi: 10.1093/bioinformatics/btt247. Epub 2013 May 1.
Langer, M., Sah, R., Veser, A., Gütlich, M., Langosch, D. (2013):"Structural properties of model phosphatidylcholine flippases."
Chem Biol., 20(1): 63-72.
Pester, O., Barrett, P.J., Hornburg, D., Hornburg, P., Proebstle, R., Widmaier, S., Kutzner, C., Duerrbaum, M., Kapurniotu, A., Sanders, C.R., Scharnagl, C., Langosch, D. (2013): "The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ-Secretase."
J Am Chem Soc, 135(4): 1317-1329.
2012
Stelzer, W. and Langosch, D. (2012):"Sequence-dependent backbone dynamics of a viral fusogen transmembrane helix"
Protein Science, 21(7):1097-1102.
Ried, C.L., Kube, S., Kirrbach, J., Langosch, D. (2012):"Homotypic Interaction and Amino Acid Distribution of Unilaterally Conserved Transmembrane Helices."
J Mol. Biol., 420(3): 251-257.
2011
Neumann, S., Langosch, D. (2011):"Conserved conformational dynamics of membrane fusion protein transmembrane domains and flanking regions indicated by sequence statistics."
Proteins, 79(8):2418-2427.
Langer, M., Langosch, D. (2011):"Is lipid flippase activity of SNARE transmembrane domains required for membrane fusion?"
FEBS Letters, 585(7):1021-1024.
Penk A, Müller M, Scheidt HA, Langosch D, Huster D. (2011): "Structure and dynamics of the lipid modifications of a transmembrane α-helical peptide determined by (2)H solid-state NMR spectroscopy."
Biochim. Biophys. Acta, 1808(3): 784-791.
2010
Quint, S., Widmaier, S., Minde, D., Hornburg, D., Langosch, D., Scharnagl, C. (2010): "Residue-specific side-chain packing determines backbone dynamics of transmembrane model helices."
Biophys. J., 99(8), 2541-2549.
Richter, L., Munter, L.M., Ness, J., Hildebrand, P.W., Dasari, M., Unterreitmeier, S., Bulic, B., Beyermann, M., Gust, R., Reif, B., Weggen, S., Langosch, D., Multhaup, G. (2010):" Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization."
Proc. Natl. Acad. Sci (PNAS), 107(33): 14597-14602.
Agrawal, P., Kiihne, S., Hollander, J., Hofmann, M., Langosch, D. & de Groot, H. (2010):" A solid-state NMR study of changes in lipid phase induced by membrane-fusogenic LV-peptides."
Biochim Biophys Acta, 1798: 202-209.
Nikolaus, J., Stöckl, M., Langosch, D., Volkmer, R. & Herrmann, A. (2010): Direct visualization of large and protein-free hemifusion diaphragms."
Biophys. J., 98(7): 1192-1199.
Poschner, B. C., Fischer, K., Herrmann, J. R., Hofmann, M. W., Langer, M. & Langosch, D. (2010): "Structural features of fusogenic model transmembrane domains that differentially regulate inner and outer leaflet mixing in membrane fusion."
Mol Membr Biol, 27(1): 1-11.
Herrmann, J., Fuchs, A., Panitz, J., Eckert, T., Unterreitmeier, S., Frishman, D. & Langosch, D. (2010):" Ionic interactions promote transmembrane helix-helix association depending on sequence context."
J. Mol. Biol., 396: 452-461.
2009
Poschner, B.C., Langosch, D. (2009): "Stabilization of conformationally dynamic helices by covalently attached acyl chains."
Protein Science, 18(8): 1801-1805.
Langosch, D., Arkin I.T. (2009): "Interaction and conformational dynamics of membrane-spanning protein helices."
Protein Sci., 18(7): 1343-1358.
Poschner, B.C., Quint, S., Hofmann, M.W., Langosch, D. (2009): "Sequence-specific conformational dynamics of model transmembrane domains determines their membrane fusogenic function."
J Mol Biol., 386(3): 733-741.
Herrmann, J.R., Panitz, J.C., Unterreitmeier, S., Fuchs, A., Frishman, D., Langosch, D. (2009): "Complex patterns of histidine, hydroxylated amino acids and the GxxxG motif mediate high-affinity transmembrane domain interactions."
J Mol Biol., 385(3): 912-923.
Diezemann, N., Weigang, L.M.M., Chakrabort, P., Frauendorf, H., Letzel, T., and Diederichsen, U. (2009): "Organisation of nucleobase functionalised beta-peptides investigated by soft electrospray ionization mass spectrometry, CID-MS/MS and IRMPD-MS/MS."
Journal of Mass Spectrometry., in press.
Lacombe-Harvey, M.-E., Fukamizo, T., Gagnon, J., Ghinet, M.G., Dennhart, N., Letzel, T., and Brzezinski, R. (2009): "Accessory active site residues of Streptomyces sp. N174 chitosanase - variations on a common theme in the lysozyme superfamily."
FEBS Journal. , 276(3):857-869.
Letzel, M., Metzner, G., and Letzel, T (2009): "Exposure assessment of the pharmaceutical diclofenac based on long-term measurements of the aquatic input."
Environmental International, 35(2):363-368. (online available)
2008
Weigang, L.M., Langosch, D., Letzel, T. (2008): "Gas-phase behavior of noncovalent transmembrane segment complexes."
Rapid Commun Mass Spectrom., 22(24): 4089-4097.
Berkemeyer, C. and Letzel, T. (2008): "LC-API-MS/MS for biological samples: Importance of hydrophobicity, molecular weight and structural development."
LC-GC Europe., 21(11): 548-561.
Stelzer, W., Poschner, B., Stalz, H., Heck, A.J.R., Langosch, D. (2008): "Sequence-specific conformational flexibility of SNARE transmembrane helices probed by hydrogen/deuterium exchange."
Biophysical Journal, 95: 1326-1335.
Adelhelm, C., Niessner, R., Pöschl, U., Letzel, T. (2008): "Analysis of large oxygenated and nitrated polycyclic aromatic hydrocarbons formed under simulated diesel engine exhaust conditions (by compound fingerprints with SPE/LC-API-MS)."
Analyt. and Bioanalyt. Chemistry, 391: 2599-2608.
Kriechbaumer, V., Weigang, L., Fließelmann, A., Letzel, T., Frey, M., Gierl, A., Glawischnig, E. (2008): "Characterization of the tryptophan synthase alpha subunit in maize"
BMC Plant Biology, 8: 44.
Dennhart, N., Fukamizo, T., Brzezinski, R., Lacombe-Harvey, M.-E., Letzel, T. (2008): "Oligosaccharide hydrolysis by chitosanase enzymes monitored by real-time electrospray ionization - mass spectrometry."
Journal of Biotechnology, 134(3-4): 253-260.
Letzel, T. (2008):"Real-time mass spectrometry in enzymology."
Analyt. and Bioanalyt. Chemistry, 390: 257-261.
Ollesch, J., Poschner, B.C., Nikolaus, J., Hofmann, M.W., Herrmann, A., Gerwert, K., Langosch, D. (2008): "Secondary structure and distribution of fusogenic LV-peptides in lipid membranes."
Eur Biophys J., 37(4): 435-445.
2007
Agrawal, P., Kiihne, S., Hollander, J., Langosch, D., de Groot H.(2007): "13C and 15N NMR evidence for peripheral intercalation of uniformly labeled fusogenic peptides incorporated in a biomimetic membrane."
Biochim Biophys Acta., 1768(12): 3020-3028.
Unterreitmeier, S., Fuchs, A., Schäffler, T., Heym, R.G., Frishman, D., Langosch, D.(2007): "Phenylalanine promotes interaction of transmembrane domains via GxxxG motifs."
J Mol Biol., 374(3): 705-718.
Langosch, D., Hofmann, M., Ungermann, C. (2007): "The role of transmembrane domains in membrane fusion."
Cell Mol Life Sci., 64 (7-8): 850-864.
Berkemeyer, C., Letzel, T. (2007): "LC-API-MS(-MS) for biological samples: Renaissance of the complementary parameter hydrophobicity, molecular weight and structural development." (German Article)
LC-GC ads, 2(4): 36-45.
J. Wünschmann, A. Beck, L. Meyer, T. Letzel, E. Grill, and K.J. Lendzian (2007): "Phytochelatins are synthesized by two vacuolar serine carboxypeptidases in Saccharomyces cerevisiae."
FEBS Letters, 581 (8): 1681-1687.
Lindner, E., Unterreitmeier, S., Ridder, A.N., Langosch, D. (2007): "An extended ToxR POSSYCCAT system for positive and negative selection of self-interacting transmembrane domains."
J Microbiol Methods., 69 (2): 298-305.
Hofmann, M.W., Poschner, B.C., Hauser, S., Langosch, D. (2007): "pH-Activated Fusogenic Transmembrane LV-Peptides."
Biochemistry, 46(13): 4204-4209.
Munter, L.M., Voigt, P., Harmeier, A., Kaden, D., Gottschalk, K.E., Weise, C., Pipkorn, R., Schaefer, M., Langosch, D., Multhaup, G. (2007): "GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42."
EMBO J., 26(6): 1702-12.
Agrawal, P., Kiihne, S., Hollander, J., Hulsbergen, F., Hofmann, M., Langosch, D., de Groot, H. (2007): "Solid State NMR Investigation of the Interaction between Biomimetic Lipid Bilayers and de novo Designed Fusogenic Peptides."
Chembiochem., 8(5): 493-496.
Poschner, B.C., Reed, J., Langosch, D., Hofmann M.W. (2007): "An automated application for deconvolution of circular dichroism spectra of small peptides."
Anal. Biochem., 363(2): 306-8.
Mascia, L., Langosch, D. (2007): "Evidence that late-endosomal SNARE multimerization complex is promoted by transmembrane segments". Biochimica et Biophysica Acta, 1768(3): 457-466.
Blum, R., Beck, A., Korte, A., Stengel, A., Letzel, T., Lendzian, K., and Grill, E. (2007): " Function of phytochelatin synthase in catabolism of gluthatione-conjugates". The Plant Journal, 49: 740-749.
Grosse, S. and Letzel, T. (2007). "Liquid chromatography / atmospheric pressure ionization mass spectrometry with post-column liquid mixing for the efficient determination of partially oxidized polycyclic aromatic hydrocarbons." Journal of Chromatography A, 1139, 75-83.
Agrawal, P.R., Hofmann, M.W., Meeuwenoord, N.J., Filippov, D.V., Stalz, H., Hulsenbergen, F., Langosch, D., Overkleeft, H.S. & de Groot, H. (2007). "Solid Phase Synthesis and Purification of Isotopically 13C, 15N Uniformly Labeled de novo Set of Membrane Fusogenic Peptides." Journal of Peptide Science , 13(2): 75-80.
2006
Lindner, E., Langosch, D. (2006). "A ToxR-based dominant-negative system to investigate heterotypic transmembrane domain interactions." PROTEINS: Structure, Function, and Bioinformatics, 65 (4): 803-807.
Hofmann, M. W., Peplowska, K., Rohde, J., Poschner, B., Ungermann, C. & Langosch, D. (2006). "Self-interaction of a SNARE transmembrane domain promotes the hemifusion-to-fusion transition in lipid mixing." J. Mol. Biol. (JMB), 364 (5):1048-1060.
Roy, R., Peplowska, K., Rohde, J., Ungermann, C. & Langosch, D. (2006). "Role of the Vam3p Transmembrane Segment in Homodimerization and SNARE Complex Formation". Biochemistry, 45: 894-902.
N. Dennhart and T. Letzel (2006) "Mass Spectrometric Real-Time Monitoring of Enzymatic Glycosidic Hydrolysis, Enzymatic Inhibition and Enzyme Complexes."
Analytical and Bioanalytical Chemistry, 386: 689-698.
2005
Ridder, A., Skupien, P., Unterreitmeier S., Langosch, D. (2005) "Tryptophan Supports Interaction of Transmembrane Helices", J. Mol. Biol. (JMB), 354, 894-902. (PDF-file)
Ridder, A.N. and Langosch, D. (2005), "Transmembrane domains in membrane protein folding, oligomerization, and function.", in Buchner, K. (ed.), in Handbook of Protein Folding. Wiley, Vol. 2. (PDF-file)
Ungermann, C., Langosch, D. (2005) "Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing", J Cell Sci., 118(17): 3819-3828. (PDF-file)
Hofmann, M. W., Stalz, H., Langosch, D. (2005) "Solid phase extraction as a tool to remove impurities and small fragments from synthetic peptides", Anal. Biochem., 344(1): 144-146. (PDF-file)
Sengupta, D., Meinhold, L., Langosch, D., Ullmann, G.M., Smith, J.C. (2005) "Understanding the energetics of helical peptide orientation in membranes", Proteins. 58(4): 913-922.
2004
Hofmann, M. W., Weise, K., Ollesch, J., Agrawal, A., Stalz, H., Stelzer, W., Hulsbergen, F., deGroot, H., Gerwert, K., Reed, J. & Langosch, D. (2004). De novo design of conformationally flexible transmembrane peptides driving membrane fusion. Proc. Natl. Acad. Sci. U S A 101, 14776-14781.
Ruan, W., Lindner, E., and Langosch, D. (2004) "The interface of a membrane-spanning leucine zipper mapped by asparagine-scanning mutagenesis", Prot. Sci. 13, 555-559. (PDF-file)
Ruan, W., Becker, V., Klingmüller, U., and Langosch, D. (2004) "The interface between the self-assembling erythropoietin receptor transmembrane segments corresponds to a heptad repeat pattern", J. Biol. Chem. 279, 3273-3279. (PDF-file)
Roy, R., Laage, R., and Langosch, D. (2004) "Synaptobrevin Transmembrane Domain Dimerization - Revisited", Biochemistry 43, 4964-4970. (PDF-file)
2003
Rohde, J., Dietrich, L., Langosch, D., Ungermann, Ch. (2003): "The Transmembrane Domain of Vam3 Affects the Composition of cis- and trans-SNARE Complexes to Pormote Homotypic Vacuole Fusion." J. Biol. Chem., Vol. 278, Issue 3, 1656-1662.
2002
Langosch, D., Lindner, E. & Gurezka, R. (2002). "In vitro selection of self-interacting transmembrane segments - Membrane proteins approached from a different perspective." IUBMB Life 54 (3), 109-113. (PDF-file)
2001
Gurezka, R. and Langosch, D. (2001) "In vitro selection of membrane-spanning leucine zipper protein-protein interaction motifs using POSSYCCAT"
J. Biol. Chem. 276, 45580-45587.
Langosch, D., Crane, J.M., Brosig, B., Hellwig, B., Tamm, L.K. and Reed, J. (2001a) "Peptide Mimics of SNARE Transmembrane Segments Drive Membrane Fusion Depending on Their Conformational Plasticity" J. Mol. Biol.311, 709-721. (PDF-file)
Langosch, D., Brosig, B. and Pipkorn, R. (2001b) "Peptide Mimics of the Vesicular Stomatitis Virus G-protein Transmembrane Segment Drive Membrane Fusion in vitro" J. Biol. Chem. 276, 32016 - 32021. (PDF-file)
Laage, R. and Langosch, D. (2001) "Strategies for prokaryotic expression of eukaryotic membrane proteins", Traffic 2, 99-104.
Kubatzky, K.F., Ruan, W., Gurezka, R., Cohen, J., Ketteler, R., Watowich, S., Neumann, D., Langosch, D. and Klingmüller, U. (2001) "Self-assembly of the transmembrane domain is a crucial mediator for signalling through the erythropoietin receptor", Current Biology 11, 110-115. (PDF-file)
Langosch, D. (2001) "Von Bausteinen zu Netzwerken", Laborjournal 8 (1), 32-33
2000
Laage, R., Rohde, J., Brosig, B. and Langosch, D. (2000) "A conserved membrane-spanning amino acid motif drives homomeric and supports heteromeric assembly of presynaptic SNARE proteins" J. Biol. Chem. 23, 17481-17487. (PDF-file)
1999
Huber, O., Kemler, R. and Langosch, D. (1999) "Mutations affecting transmembrane segment interaction impair adhesiveness of E-cadherin", J. Cell Sci. 112, 4414-4423. (PDF-file)
Langosch, D. (1999) "Molekulare Erkennung zwischen membranständigen Proteindomänen: struktur- und zellbiologische Aspekte" Biospektrum 2, 101-105. (PDF-file)
Gurezka, R., Laage, R., Brosig, B. and Langosch, D. (1999) "A Heptad Motif of Leucine Residues Found in Membrane Proteins Can Drive Self-Assembly of Artificial Transmembrane Segments", (PDF-file)
J. Biol. Chem. 274(14), 9265-9270.
1998
Brosig, B. and Langosch, D. (1998) "The dimerization motif of the glycophorin A transmembrane segment in membranes: importance of glycine residues" Prot. Sci., 7, 1052-1056
Langosch, D. and Heringa, J. (1998) "Interaction of Transmembrane Helices by a Knobs-Into-Holes Geometry Characteristic of Soluble Coiled Coils", Proteins, 31, 150-160.
1997
Laage, R. and Langosch, D. (1997) "Dimerization of the Synaptic Vesicle Protein Synaptobrevin Depends on Specific Residues of its Transmembrane Segment", Eur. J. Biochem. 249, 540-546.
1996
Langosch, D., Brosig, B., Kolmar, H., and Fritz, H.-J. (1996) "Dimerisation of the Glycophorin A Transmembrane Segment in Membranes Probed with the ToxR Transcription Activator",
J. Mol. Biol 263, 525-530.
1995
Langosch, D. (1995) "Die funktionelle Architektur ligandengesteuerter Ionenkanalproteine", Biospektrum 5, 34-41.
Langosch, D. (1995) "Inhibitory Glycine Receptors" In:" Ligand and Voltage-Gated Ion Channels", (R.A. North, ed.), Boca Raton, 291-305.
Morr, J., Rundström, N., Betz, H., Langosch, D., and Schmitt, B. (1995) "Baculovirus-driven expression and purification of glycine receptor a1 homo-oligomers", FEBS Lett. 368, 495-499.
Laube, B., Langosch, D., Betz, H., and Schmieden, V. (1995) "Hyperekplexia mutations of the glycine receptor unmask the inhibitory subsite for beta-amino-acids", Neuroreport 6, 897-900.
Meyer, G., Kirsch, A., Betz, H., and Langosch, D. (1995) "Identification of a gephyrin binding motif on the glycine receptor beta-subunit", Neuron 15, 563-572.
1994
Langosch, D., Laube, B., Rundström, N., Schmieden, V., Bormann, J., and Betz, H. (1994) "Decreased Agonist Affinity and Elementary Conductance of Mutant Glycine Receptors Associated with Human Hereditary Hyperekplexia", EMBO J. 13, 4223-4228.
Rundström, N., Schmieden, V., Betz, H., Bormann, J., and Langosch, D. (1994) "Cyanotriphenylborate - a Novel Subtype-Specific Blocker of Glycine Receptor Chloride Channels",
Proc. Natl. Acad. Sci. USA 91, 8950-8954.
1993
Langosch, D., Kirsch, A., Herbold, A., Bormann, J., Schmieden, V., and Betz, H. (1993) "Importance of Arg219 for correct biogenesis of glycine receptor a1 homooligomers",
FEBS Lett. 336, 540-544.
Bormann, J., Rundström, N., Betz, H., and Langosch, D. (1993) "Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and heterooligomers",
EMBO J. 12, 3729-3737.
1992
Pribilla, I., Takagi, T., Langosch, D., Bormann, J., and Betz, H. (1992) "The Atypical M2 Segment of the b Subunit confers Picrotoxinin Resistance to Inhibitory Glycine Receptor Channels",
EMBO J., 11, 4305-4311.
Langosch, D., Pribilla, I., Takagi, T., Hartung, K., and Bormann, J. (1992) in: "Membrane proteins: structures, interactions and models" (Pullman, A., Jortner, J., and Pullman, B. , Eds.), pp. 233-241, Kluwer, Dordrecht.
Prior, P., Schmitt, B., Grenningloh, G., Pribilla, I., Multhaup, G., Beyreuther, K., Maulet, Y., Werner, P., Langosch, D., Kirsch, A., and Betz, H. (1992) "Primary Structure and Alternative Splice Variants of Gephyrin, a Putative Glycine Receptor-Tubulin Linker Protein" Neuron 8, 1-10.
Langosch, D., Hoch, W., and Betz, H. (1992) "The 93 kDa protein gephyrin and tubulin associated with the inhibitory glycine receptor are phosphorylated by an endogenous protein kinase"
FEBS Lett. 298, 113-117.
1991
Betz, H., Kuhse, J., Schmieden, V., Malosio, M.-L., Langosch, D., Prior, P., Schmitt, B., and Kirsch, J. (1991) "How to build a glycinergic postsynaptic membrane", J. Cell Science 15, 23-25.
Betz, H., Langosch, D., Hoch, W., Prior, P., Pribilla, I., Kuhse, J., Schmieden, V., Malosio, M.-L., Matzenbach, B., Holzinger, F., Kuryatow, A., Schmitt, B., Maulet, Y. and Becker, C.-M. (1991) "Structure and Expression of Inhibitory Glycine Receptors" in: "Neuroreceptor Mechanisms in Brain", (S. Kito et al., Eds.), pp 421-429, Plenum Press, New York.
Langosch, D., Hartung, K., Grell, E., Bamberg, E., and Betz, H. (1991) "Ion channel formation by synthetic transmembrane segments of the inhibitory glycine receptor - a model study",
Biochim. Biophys. Acta 1063, 36-44.
Kirsch, J., Langosch, D., Prior, P., Littauer, U. Z., Schmitt, B., and Betz, H. (1991) "The 93-kDa glycine receptor-associated protein binds to tubulin" J. Biol. Chem. 266, 22242-22245.
1990
Langosch, D., Becker, C.-M., and Betz, H. (1990) "The Inhibitory Glycine Receptor - a Ligand-Gated Chloride Channel of the Central Nervous System", European J. Biochem. 194, 1-8.
Langosch, D., Betz, H. and Becker, C.-M. (1990) "Molecular Structure and Developmental Regulation of the Inhibitory Glycine Receptor" in: Glycine Neurotransmission" (O.O. Ottersen und J. Storm-Mathisen, Eds.), pp 67-83, Wiley, New York.
1998
Langosch, D., Grenningloh, G., Schmieden, V., Prior, P., Malosio, M.-L., Schmitt, B., and Betz, H. (1988) "The Postsynaptic Glycine Receptor - a Member of the Neurotransmitter-Gated Channel Protein Family" in: "Molecular Biology of Neuroreceptors and Ion Channels", (A. Maelicke, ed.), pp. 125-130, Springer, Heidelberg.
Thomas, L., Hartung, K., Langosch, D., Rehm, H., Bamberg, E., Franke, W.W., and Betz, H. (1988) "Identification of Synaptophysin as a Hexameric Channel Protein of the Synaptic Vesicle Membrane" Science 242, 1050-1053.
Langosch, D., Thomas, L., and Betz, H. (1988) "Conserved Quaternary Structure of Ligand-gated Ion Channels: The Postsynaptic Glycine Receptor is a Pentamer" Proc. Natl. Acad. Sci. USA 85, 7394-7398.
1986
Hales, B.J., Langosch, D.J., and Case, E.E. (1986) "Isolation of a Second Nitrogenase Fe-Protein from Azotobacter vinellandii" J. Biol. Chem. 261, 15301-15306.