Metabolic reprogramming during aging

Dr. Britta Spanier

Aging is a dynamic process that comprises tissue-specific modulation of gene expression and metabolic status. We are combining genetic model organisms (Caenorhabditis elegans, Mus musculus) with in vitro analysis in human cells to chart the role of nuclear hormone receptors (NHR) as transcriptional and metabolic regulators in aging and longevity.

Literature Dr. Spanier