News

Congratulations to Barabar for her recent contribution to understand gene repression by the glucocorticoid receptor.
Machine learning reveals STAT motifs as predictors for GR-mediated gene repression

We are looking for a bachelor student or HiWi for histological analysis of arteriosclerotic plaques as consequence of Western diet and the role of nuclear receptors. Starting date April 2023. Interested? Contact Franziska Greulich.

Happy Holidays!

Latest publications:

Collaboration with Herve Guillou, Catherine Postic and Michael Schupp:
ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Collaboration with Max Delbrück Center Berlin:
Integrative analysis of macrophage ribo-Seq and RNA-Seq data define glucocorticoid receptor regulated inflammatory response genes into distinct regulatory classes

New review article:
How to tame your genes: mechanisms of inflammatory gene repression by glucocorticoids

TUM PREP is coming up in 2023 soon. We loved to have had TUM PREP student Kalina visiting this year. For more Informations see the TUM PREP webpage.

Labretreat 2022 Reitenhaslach/Burghausen
Two days of great scientific talks and nice (hot) weather.

Congratulations to Henriette Uhlenhaut and Sara Della Torre for the 2022 Science Award of the City of Freising!

Latest publications:

Collaboration with the Kooijman lab:
Angiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue

Collaboration with the Gachon lab:
Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

Collaboration with Sara Della Torre and Adriana Maggi:
Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α

Collaboration with the Charite Berlin:
Cardioprotective Effects of Palmitoleic Acid (C16:1n7) in a Mouse Model of Catecholamine-Induced Cardiac Damage Are Mediated by PPAR Activation

We are now part of the ADMIRE network:
Mineralocorticoid receptors in non-alcoholic fatty liver disease

Franziska Greulich together with Sabine Vettorazzi from the Comparative Molecular Endocrinology Ulm University receive 800,000 € DFG funding to study the reversible cellular and genomic changes induced by glucocorticoid long-term treatment.

New publication: Enhancer RNA Expression in Response to Glucocorticoid Treatment in Murine Macrophages

New publication (preprint): BRG1 defines a genomic subset of inflammatory genes transcriptionally controlled by the glucocorticoid receptor

We are now part of the CRC/TRR333 - BATenergy.

Labretreat 2021 Reitenhaslach/Burghausen
Two days of great scientific talks.

"Chromatin Morning“ on December 9

Bachelor/Master Projects at TUM or HMGU (Helmholtz Zentrum München).

Possible Projects and more, please contact us.

New publication: SETD1A/COMPASS mediates anti-inflammatory glucocorticoid function

Virtual Holiday Party and 'Lab Awards', including most irrelevant result, ugliest blot/figure
and highest number of failed NGS runs.

Labretreat Reitenhaslach/Burghausen
Celebrating 1 year of Metabolic Programming @TUM and 7 years of Endocrinology @HDC!

New publication: Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

How does Dexamethasone curb inflammation?

Collaboration with University of Padova, Italy

Exercise-dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF-SRF signaling

'Anti-inflammatory glucocorticoid action' review article

Excited about a lot of new lab equipment!

WZW-Neujahrsempfang 2020

Diet reprograms glucocorticoid rhythms (Nature Reviews Endocrinology)

Appointment of Prof. Uhlenhaut by TUM President Herrmann.