DR. GUILLAUME MÉDARD

Position: Lecturer / Group Leader Chemical Proteomics
Room: 005
Category: Scientific Staff
Phone: +49 - (0)8161 - 712059
Email: g.medard[at]tum.de

Publications

2022

  • Gabriel, Wassim; The, Matthew; Zolg, Daniel P.; Bayer, Florian P.; Shouman, Omar; Lautenbacher, Ludwig; Schnatbaum, Karsten; Zerweck, Johannes; Knaute, Tobias; Delanghe, Bernard; Huhmer, Andreas; Wenschuh, Holger; Reimer, Ulf; Médard, Guillaume; Kuster, Bernhard; Wilhelm, Mathias: Prosit-TMT: Deep Learning Boosts Identification of TMT-Labeled Peptides. Analytical Chemistry 94 (20), 2022, 7181-7190 mehr…
  • Lechner, Severin; Malgapo, Martin Ian P.; Grätz, Christian; Steimbach, Raphael R.; Baron, Agnes; Rüther, Patrick; Nadal, Simon; Stumpf, Carmen; Loos, Christina; Ku, Xin; Prokofeva, Polina; Lautenbacher, Ludwig; Heimburg, Tino; Würf, Vivian; Meng, Chen; Wilhelm, Mathias; Sippl, Wolfgang; Kleigrewe, Karin; Pauling, Josch K.; Kramer, Karl; Miller, Aubry K.; Pfaffl, Michael W.; Linder, Maurine E.; Kuster, Bernhard; Médard, Guillaume: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nature Chemical Biology, 2022 mehr…
  • Lo, Wen-Ting; Belabed, Hassane; Kücükdisli, Murat; Metag, Juliane; Roske, Yvette; Prokofeva, Polina; Ohashi, Yohei; Horatscheck, André; Cirillo, Davide; Krauss, Michael; Schmied, Christopher; Neuenschwander, Martin; von Kries, Jens Peter; Médard, Guillaume; Kuster, Bernhard; Perisic, Olga; Williams, Roger L.; Daumke, Oliver; Payrastre, Bernard; Severin, Sonia; Nazaré, Marc; Haucke, Volker: Development of selective inhibitors of phosphatidylinositol 3-kinase C2α. Nature Chemical Biology, 2022 mehr…
  • Prokofeva, Polina; Höfer, Stefanie; Hornisch, Maximilian; Abele, Miriam; Kuster, Bernhard; Médard, Guillaume: Merits of Diazirine Photo-Immobilization for Target Profiling of Natural Products and Cofactors. ACS Chemical Biology, 2022 mehr…
  • Steimbach, Raphael R.; Herbst-Gervasoni, Corey J.; Lechner, Severin; Stewart, Tracy Murray; Klinke, Glynis; Ridinger, Johannes; Géraldy, Magalie N. E.; Tihanyi, Gergely; Foley, Jackson R.; Uhrig, Ulrike; Kuster, Bernhard; Poschet, Gernot; Casero, Robert A., Jr.; Médard, Guillaume; Oehme, Ina; Christianson, David W.; Gunkel, Nikolas; Miller, Aubry K.: Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. Journal of the American Chemical Society 144 (41), 2022, 18861-18875 mehr…

2021

  • Knecht, Peter; Zhang, Bodong; Reichert, Joachim; Duncan, David A.; Schwarz, Martin; Haag, Felix; Ryan, Paul T. P.; Lee, Tien-Lin; Deimel, Peter S.; Feulner, Peter; Allegretti, Francesco; Auwärter, Willi; Médard, Guillaume; Seitsonen, Ari Paavo; Barth, Johannes V.; Papageorgiou, Anthoula C.: Assembly and Manipulation of a Prototypical N-Heterocyclic Carbene with a Metalloporphyrin Pedestal on a Solid Surface. Journal of the American Chemical Society 143 (11), 2021, 4433-4439 mehr…

2019

  • Jing, Chao; Zhang, Bodong; Synkule, Sabine; Ebrahimi, Maryam; Riss, Alexander; Auwärter, Willi; Jiang, Li; Médard, Guillaume; Reichert, Joachim; Barth, Johannes V.; Papageorgiou, Anthoula C.: Snapshots of Dynamic Adaptation: Two‐Dimensional Molecular Architectonics with Linear Bis‐Hydroxamic Acid Modules. Angewandte Chemie International Edition 58 (52), 2019, 18948-18956 mehr…
  • Reinecke, Maria; Heinzlmeir, Stephanie; Wilhelm, Mathias; Médard, Guillaume; Klaeger, Susan; Kuster, Bernhard: Kinobeads: A Chemical Proteomic Approach for Kinase Inhibitor Selectivity Profiling and Target Discovery. Target Discovery and Validation: Methods and Strategies for Drug Discovery, 2019, 97--130 mehr…
  • Reinecke, Maria; Ruprecht, Benjamin; Poser, Sandra; Wiechmann, Svenja; Wilhelm, Mathias; Heinzlmeir, Stephanie; Kuster, Bernhard; Médard, Guillaume: Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors. ACS Chemical Biology 14 (4), 2019, 655-664 mehr…

2018

  • Bader, Matthias; Dunkel, Andreas; Wenning, Mareike; Kohler, Bernd; Medard, Guillaume; del Castillo, Estela; Gholami, Amin; Kuster, Bernhard; Scherer, Siegfried; Hofmann, Thomas: Dynamic Proteome Alteration and Functional Modulation of Human Saliva Induced by Dietary Chemosensory Stimuli. Journal of Agricultural and Food Chemistry 66 (22), 2018, 5621-5634 mehr…
  • Médard, Guillaume; Papageorgiou, Anthoula C.: Surface anchors target golden bullets. Nature Chemistry 11 (1), 2018, 20-22 mehr…
  • Roehrer, Simon; Behr, Juergen; Stork, Verena; Ramires, Mara; Médard, Guillaume; Frank, Oliver; Kleigrewe, Karin; Hofmann, Thomas; Minceva, Mirjana: Xanthohumol C, a minor bioactive hop compound: Production, purification strategies and antimicrobial test. Journal of Chromatography B 1095, 2018, 39-49 mehr…
  • Tröster, Alix; Heinzlmeir, Stephanie; Berger, Benedict-Tilman; Gande, Santosh L.; Saxena, Krishna; Sreeramulu, Sridhar; Linhard, Verena; Nasiri, Amir H.; Bolte, Michael; Müller, Susanne; Kuster, Bernhard; Médard, Guillaume; Kudlinzki, Denis; Schwalbe, Harald: NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem 13 (16), 2018, 1629-1633 mehr…
  • Zolg, Daniel Paul; Wilhelm, Mathias; Schmidt, Tobias; Médard, Guillaume; Zerweck, Johannes; Knaute, Tobias; Wenschuh, Holger; Reimer, Ulf; Schnatbaum, Karsten; Kuster, Bernhard: ProteomeTools: Systematic Characterization of 21 Post-translational Protein Modifications by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Using Synthetic Peptides. Molecular & Cellular Proteomics 17 (9), 2018, 1850-1863 mehr…

2017

  • Arduino, Daniela M.; Wettmarshausen, Jennifer; Vais, Horia; Navas-Navarro, Paloma; Cheng, Yiming; Leimpek, Anja; Ma, Zhongming; Delrio-Lorenzo, Alba; Giordano, Andrea; Garcia-Perez, Cecilia; Médard, Guillaume; Kuster, Bernhard; García-Sancho, Javier; Mokranjac, Dejana; Foskett, J. Kevin; Alonso, M. Teresa; Perocchi, Fabiana: Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening. Molecular Cell 67 (4), 2017, 711-723.e7 mehr…
  • Delius, Judith; Médard, Guillaume; Kuster, Bernhard; Hofmann, Thomas: Effect of Astringent Stimuli on Salivary Protein Interactions Elucidated by Complementary Proteomics Approaches. Journal of Agricultural and Food Chemistry 65 (10), 2017, 2147-2154 mehr…
  • Delius, Judith; Trautmann, Simone; Médard, Guillaume; Kuster, Bernhard; Hannig, Matthias; Hofmann, Thomas: Label-free quantitative proteome analysis of the surface-bound salivary pellicle. Colloids and Surfaces B: Biointerfaces 152, 2017, 68-76 mehr…
  • Heinzlmeir, Stephanie; Lohse, Jonas; Treiber, Tobias; Kudlinzki, Denis; Linhard, Verena; Gande, Santosh Lakshmi; Sreeramulu, Sridhar; Saxena, Krishna; Liu, Xiaofeng; Wilhelm, Mathias; Schwalbe, Harald; Kuster, Bernhard; Médard, Guillaume: Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem 12 (12), 2017, 999-1011 mehr…
  • Jiang, Li; Zhang, Bodong; Médard, Guillaume; Seitsonen, Ari Paavo; Haag, Felix; Allegretti, Francesco; Reichert, Joachim; Kuster, Bernhard; Barth, Johannes V.; Papageorgiou, Anthoula C.: N-Heterocyclic carbenes on close-packed coinage metal surfaces: bis-carbene metal adatom bonding scheme of monolayer films on Au, Ag and Cu. Chemical Science 8 (12), 2017, 8301-8308 mehr…
  • Klaeger, Susan; Heinzlmeir, Stephanie; Wilhelm, Mathias; Polzer, Harald; Vick, Binje; Koenig, Paul-Albert; Reinecke, Maria; Ruprecht, Benjamin; Petzoldt, Svenja; Meng, Chen; Zecha, Jana; Reiter, Katrin; Qiao, Huichao; Helm, Dominic; Koch, Heiner; Schoof, Melanie; Canevari, Giulia; Casale, Elena; Depaolini, Stefania Re; Feuchtinger, Annette; Wu, Zhixiang; Schmidt, Tobias; Rueckert, Lars; Becker, Wilhelm; Huenges, Jan; Garz, Anne-Kathrin; Gohlke, Bjoern-Oliver; Zolg, Daniel Paul; Kayser, Gian; Vooder, Tonu; Preissner, Robert; Hahne, Hannes; Tõnisson, Neeme; Kramer, Karl; Götze, Katharina; Bassermann, Florian; Schlegl, Judith; Ehrlich, Hans-Christian; Aiche, Stephan; Walch, Axel; Greif, Philipp A.; Schneider, Sabine; Felder, Eduard Rudolf; Ruland, Juergen; Médard, Guillaume; Jeremias, Irmela; Spiekermann, Karsten; Kuster, Bernhard: The target landscape of clinical kinase drugs. Science 358 (6367), 2017, eaan4368 mehr…
  • Lohse, Jonas; Schindl, Alexandra; Danda, Natasha; Williams, Chris P.; Kramer, Karl; Kuster, Bernhard; Witte, Martin D.; Médard, Guillaume: Target and identify: triazene linker helps identify azidation sites of labelled proteins via click and cleave strategy. Chem. Commun. 53 (87), 2017, 11929-11932 mehr…
  • Lohse, Jonas; Swier, Lotteke J.Y.M.; Oudshoorn, Ruben C.; Médard, Guillaume; Kuster, Bernhard; Slotboom, Dirk-Jan; Witte, Martin D.: Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides. Bioconjugate Chemistry 28 (4), 2017, 913-917 mehr…
  • Schneider, Katharina S.; Groß, Christina J.; Dreier, Roland F.; Saller, Benedikt S.; Mishra, Ritu; Gorka, Oliver; Heilig, Rosalie; Meunier, Etienne; Dick, Mathias S.; Ćiković, Tamara; Sodenkamp, Jan; Médard, Guillaume; Naumann, Ronald; Ruland, Jürgen; Kuster, Bernhard; Broz, Petr; Groß, Olaf: The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. Cell Reports 21 (13), 2017, 3846-3859 mehr…
  • Stolle, Theresa; Grondinger, Freya; Dunkel, Andreas; Meng, Chen; Médard, Guillaume; Kuster, Bernhard; Hofmann, Thomas: Salivary Proteome Patterns Affecting Human Salt Taste Sensitivity. Journal of Agricultural and Food Chemistry 65 (42), 2017, 9275-9286 mehr…

2016

  • Groß, Christina J.; Mishra, Ritu; Schneider, Katharina S.; Médard, Guillaume; Wettmarshausen, Jennifer; Dittlein, Daniela C.; Shi, Hexin; Gorka, Oliver; Koenig, Paul-Albert; Fromm, Stephan; Magnani, Giovanni; Ćiković, Tamara; Hartjes, Lara; Smollich, Joachim; Robertson, Avril A.B.; Cooper, Matthew A.; Schmidt-Supprian, Marc; Schuster, Michael; Schroder, Kate; Broz, Petr; Traidl-Hoffmann, Claudia; Beutler, Bruce; Kuster, Bernhard; Ruland, Jürgen; Schneider, Sabine; Perocchi, Fabiana; Groß, Olaf: K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. Immunity 45 (4), 2016, 761-773 mehr…
  • Heinzlmeir, S. ; Kudlinzki, D. ; Sreeramulu, S. ; Klaeger, S. ; Gande, S. ; Linhard, V. ; Wilhelm, M. ; Qiao, H. ; Helm, D. ; Ruprecht, B. ; Saxena, K. ; Medard, G. ; Schwalbe, H. ; Kuster, B.: Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem Biol, 2016 mehr…
  • Klaeger, Susan; Gohlke, Bjoern; Perrin, Jessica; Gupta, Vipul; Heinzlmeir, Stephanie; Helm, Dominic; Qiao, Huichao; Bergamini, Giovanna; Handa, Hiroshi; Savitski, Mikhail M; Bantscheff, Marcus; Médard, Guillaume; Preissner, Robert; Kuster, Bernhard: Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chemical Biology 11 (5), 2016, 1245-1254 mehr…
  • Weigt, David; Hopf, Carsten; Médard, Guillaume: Studying epigenetic complexes and their inhibitors with the proteomics toolbox. Clinical Epigenetics 8 (1), 2016 mehr…

2015

  • Koch, Heiner; Busto, M. Estela Del Castillo; Kramer, Karl; Médard, Guillaume; Kuster, Bernhard: Chemical Proteomics Uncovers EPHA2 as a Mechanism of Acquired Resistance to Small Molecule EGFR Kinase Inhibition. Journal of Proteome Research 14 (6), 2015, 2617-2625 mehr…
  • Médard, Guillaume; Pachl, Fiona; Ruprecht, Benjamin; Klaeger, Susan; Heinzlmeir, Stephanie; Helm, Dominic; Qiao, Huichao; Ku, Xin; Wilhelm, Mathias; Kuehne, Thomas; Wu, Zhixiang; Dittmann, Antje; Hopf, Carsten; Kramer, Karl; Kuster, Bernhard: Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling. Journal of Proteome Research 14 (3), 2015, 1574-1586 mehr…
  • Ruprecht, Benjamin; Zecha, Jana; Heinzlmeir, Stephanie; Médard, Guillaume; Lemeer, Simone; Kuster, Bernhard: Evaluation of Kinase Activity Profiling Using Chemical Proteomics. ACS Chemical Biology 10 (12), 2015, 2743-2752 mehr…

2014

  • Ku, Xin; Heinzlmeir, Stephanie; Helm, Dominic; Médard, Guillaume; Kuster, Bernhard: New Affinity Probe Targeting VEGF Receptors for Kinase Inhibitor Selectivity Profiling by Chemical Proteomics. Journal of Proteome Research 13 (5), 2014, 2445-2452 mehr…
  • Ku, Xin; Heinzlmeir, Stephanie; Liu, Xiaofeng; Médard, Guillaume; Kuster, Bernhard: A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors. Journal of Proteomics 96, 2014, 44-55 mehr…
  • Médard, Guillaume: A route to the 9,10-secosteroid astrogorgiadiol featuring a key sp2–sp3 Suzuki type cross-coupling. Tetrahedron 70 (2), 2014, 186-196 mehr…
  • Ruprecht, Benjamin; Koch, Heiner; Medard, Guillaume; Mundt, Max; Kuster, Bernhard; Lemeer, Simone: Comprehensive and Reproducible Phosphopeptide Enrichment Using Iron Immobilized Metal Ion Affinity Chromatography (Fe-IMAC) Columns. Molecular & Cellular Proteomics 14 (1), 2014, 205-215 mehr…

2013

  • Hahne, Hannes; Pachl, Fiona; Ruprecht, Benjamin; Maier, Stefan K; Klaeger, Susan; Helm, Dominic; Médard, Guillaume; Wilm, Matthias; Lemeer, Simone; Kuster, Bernhard: DMSO enhances electrospray response, boosting sensitivity of proteomic experiments. Nature Methods 10 (10), 2013, 989-991 mehr…
  • Pachl, Fiona; Plattner, Patrik; Ruprecht, Benjamin; Médard, Guillaume; Sewald, Norbert; Kuster, Bernhard: Characterization of a Chemical Affinity Probe Targeting Akt Kinases. Journal of Proteome Research 12 (8), 2013, 3792-3800 mehr…